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Oxymetholone (also known as anapolon or anadrol) is a very drastic synthetic steroid, 17-alpha-alkylated modification of dihydrotestosterone.

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Later there where created non-steroidal drugs that effectively could treat anaemia and osteoporosis; because of this anapolon lost his popularity and by 1993 Syntex decided to cease the production of the drug, as well as other manufacturers did. By its performance parameters oxymetholone is most similar to methandienone. As with methandienone, it provokes not only active muscle bulking, but also a significant increase in power performance.

However, a large part of the gained weight is because of water retention in the body, which can lead to high blood pressure on cycle. . Oxymetholone is a derivative of dihydrotestosterone, which gives it a chemical structure that does not aromatize. Despite the fact that oxymetholone does not directly convert to estradiol, it itself has pronounced estrogenic properties.

It should be remembered that because of this peculiarity only antiestrogens would be able to combat with estrogenic side effects, but not aromatase inhibitors, because aromatase is not involved into the process. Some suggest that oxymetholone`s estrogenic activity relates to the progestogenic one, like with nandrolones. Side effects may be similar.

However, medical studies have shown that oxymetholone does not possess any progestogenic activity.

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