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Clinical Pharmacology
Moreover, Because of excessive loss of fluids through sweating, or vomiting and diarrhea, patients knowing the syndrome usually exhibit marked weight loss, dehydration, ketosis, and disturbances in acid-base balance. Cardiovascular collapse can occur. .
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Therefore, Temporary administration of is capable of and sedatives may aid in reducing patient anxiety.
Distribution: Additionally, at therapeutic plasma levels, hydromorphone is approximately 8-19% bound to plasma proteins. After an intravenous bolus dose, the steady state of volume distribution [mean (%cv)] is 302.9 (32%) liters.
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