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Substance: IGF-1 LR3
Package: 1 kit (5 vials – 200 mcg/vial)
Common Name(s): Insulin-like Growth Factor-1 LR3 .
IGF-1 therefore allows growth or at least a limitation of bone loss related to age and aging.The
The level of IGFBP that binds this IGF-1 remains stable but IGFBP releases its IGF-1 during physical activity.
The free fraction of IGF-1, the active form and not bound to IGFBP, can apply its tissue effects .
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Alteration of the gene IGF1 causes abnormality syndrome involving growth retardation , mental retardation and deafness .
This syndrome can be partially improved by the administration of recombinant IGF-1.
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Alteration of the receptor gene to IGF-1 ( IGF1R ) also results in slowing down development at the intra-uterine life.
The hormone could thus decrease the progression of atheroma by several movements.
IGF-1 is a linear peptide of 70 amino acids consisting of 4 domains (B, C, A, D).
Whose domains B and A are similar to those of insulin.
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GH will induce an increase in hepatic secretion of IGF-1 within a few hours.
The level of IGFBP that binds this IGF-1 remains stable but IGFBP releases its IGF-1 during physical activity.
It was discovered and characterized in 1987 by the team of D r Mike Davis ( Imperial College London , UK ) together with that of the PRobin Jokin.
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Due to the fact that IGFs stimulate the proliferation of differentiated chondrocytes, leading to enlargement of the conjugation cartilage and lengthening of the bone.
In addition, IGFs promote the growth of all tissues, stimulate protein synthesis and improve Ca 2+ uptake .
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